Too much of a good thing can be downright disastrous. After taking 8 to 12 drops of concentrated Vitamin D every day for two-and-a-half years, a 54-year-old man in Canada has inadvertently and permanently damaged his kidneys.
He used it as prescribed by a naturopath at a dose well above the recommended daily allowance, and now it has taken a year of treatment for the patient's blood to return to normal, while some organs never will - he is ultimately burdened with stage 3B chronic kidney disease.
The physicians who published his case in a medical journal are worried that others might fall into the same innocent trap.
"Our experience informs us that patients and clinicians should be better informed about the risks regarding the unfettered use of vitamin D," the authors suggest.
"Given new findings from t，he US Preventive Services Task Force, current Canadian guidelines regarding its use in low-risk individuals should be revisited."
“鑑於美國預防服務工作組(US Preventive Services Task Force)的新發現，應該重新審視加拿大目前關於在低風險人羣中使用該藥物的指導方針。”
Vitamin D toxicity is a rare but potentially serious condition usually caused by megadoses of supplements, not by diet or excessive sun exposure.
In this particular case though, sun exposure was probably what broke the camel's back. Upon returning home from a holiday during which the man had sunbathed daily for eight hours or more, the middle-aged patient's family physician noticed a worrying sign.
It appeared that in his two week trip to Southeast Asia, the patient's creatine levels had suddenly skyrocketed, shooting from 100 μmol/L to 132 μmol/L. Given that the kidneys usually filter excess creatine out, the results suggested some sort of malfunction.
作為名詞時，downright表示“直截了當的; 明白的”。如downright lie 彌天大謊